The science behind epigenetics and how and when they are activated during water fasting and dry fasting.
Proteolytic Enzymes
Once you go deep into the research about ketosis, fat catabolism, starvation, fasting, you start to make key connections. Water fasting also gets into a protein conservation stage, but it takes 3x longer than dry fasting. That's why dry fasting is so much better for muscle conservation and why sometimes it's good to help speed up the ketosis by working out and getting rid of glycogen faster. You speed up the post-absorptive stage, by increasing insulin which helps lower blood glucose, push it into muscles, while at the same time depleting it, which overall starts the processes for phase 2: the gluconeogenenic stage.
June 2023
Folate and BH4 Supplementation Link
The above data provides a link between the two pathways, but is there any evidence that dietary alteration or nutritional supplementation can have a positive effect? If BH2 levels are high then THF levels appear to be reduced.16 However, BH2 levels only reach these severely high levels in the complete absence of QDPR, which will not apply to any readers here. Supplementation with BH4 may increase the levels of BH2 but there is no evidence that this has a negative health effect, or a positive effect on folate activity. Let’s look at it the other way. Low levels of BH4 are associated with several health issues. Can supplementation with MTHF (the preferred supplementary form) increase BH4 levels? Interestingly, it does seem possible, although the effect is not processed through QDPR or DHFR. Rather, studies have shown that MTHF supplementation can increase BH4 levels by preventing its oxidation into BH2 and by supplementing BH4 activity with NOS enzymes further preventing its degradation.1718 Therefore, MTHF supplementation alone, or in conjunction with BH4, may prove beneficial to those with low levels of BH4.